Description

1-Boc-Pyrrole-2-Boronic Acid, Pinacol Ester is a high-purity, protected boronic acid ester building block essential for modern synthetic chemistry. This compound is a critical intermediate in the synthesis of complex molecules, particularly in pharmaceutical research and development. It is primarily used by medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for constructing novel pyrrole-containing scaffolds via cross-coupling reactions.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for the palladium-catalyzed formation of carbon-carbon bonds, enabling the synthesis of biaryl and heterobiaryl structures.
• Pharmaceutical Intermediate: Serves as a versatile building block in the research and development of active pharmaceutical ingredients (APIs), especially those containing functionalized pyrrole motifs.
• Agrochemical Synthesis: Used in the creation of novel herbicides, fungicides, and insecticides that require specific heterocyclic architectures.
• Material Science Research: Employed in the development of organic electronic materials, such as conductive polymers and organic light-emitting diodes (OLEDs).
• Chemical Biology & Probe Development: Facilitates the synthesis of molecular probes and labeled compounds for studying biological systems and drug-target interactions.
• Scale-up and Process Chemistry: Provides a stable, handleable form of the sensitive boronic acid functionality for optimization and kilogram-scale manufacturing processes.

Basic Information

Product Name	1-Boc-Pyrrole-2-Boronic Acid, Pinacol Ester
CAS No.	1072944-98-9
Molecular Formula	C15H24BNO4
Molecular Weight	293.17 g/mol
Synonyms	1-(tert-Butoxycarbonyl)-1H-pyrrole-2-boronic acid pinacol ester; 1-Boc-2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrole; 1H-Pyrrole-2-boronic acid, 1-[(1,1-dimethylethoxy)carbonyl]-, 4,4,5,5-tetramethyl-1,3,2-dioxaborolane ester; tert-Butyl 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrole-1-carboxylate; 1-Boc-2-pyrrolylboronic acid pinacol ester; 1-Boc-pyrrole-2-Bpin.
EINECS	Contact for details

Quality Control

Our 1-Boc-Pyrrole-2-Boronic Acid, Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR (1H, 13C, 11B), and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support development and regulatory needs with comprehensive documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) to prevent oxidation and hydrolysis. Keep away from strong acids and strong bases. Allow the sealed container to reach ambient temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.