Description

1-Boc-Indole-2-Boronic Acid, Pinacol Ester is a high-purity, protected boronic ester building block essential for modern synthetic organic chemistry. This compound matters as a key intermediate in the Suzuki-Miyaura cross-coupling reaction, enabling the efficient construction of complex, functionalized indole derivatives. Pharmaceutical, agrochemical, and advanced materials researchers need it for the development of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A crucial building block for synthesizing novel indole-based drug candidates, including kinase inhibitors and receptor modulators.
• Agrochemical Research: Used in the discovery and development of new herbicides, fungicides, and plant growth regulators featuring the indole scaffold.
• Material Science: Enables the creation of functionalized organic semiconductors, OLED materials, and liquid crystals via palladium-catalyzed cross-coupling.
• Chemical Biology & Proteolysis Targeting Chimeras (PROTACs): Serves as a versatile linker component for constructing bifunctional molecules in targeted protein degradation research.
• Academic & Contract Research: A valuable reagent for methodology development and complex molecule synthesis in academic and industrial R&D laboratories.

Basic Information

Product Name	1-Boc-Indole-2-Boronic Acid, Pinacol Ester
CAS No.	1072944-96-7
Molecular Formula	C19H26BNO4
Molecular Weight	343.23 g/mol
Synonyms	1-(tert-Butoxycarbonyl)-1H-indole-2-boronic acid pinacol ester; 1-Boc-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole; tert-Butyl 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole-1-carboxylate; 1-Boc-indole-2-boronic acid pinacol ester; 1-Boc-2-indoleboronic acid pinacol ester; 1-Boc-2-boronoindole pinacol ester; BOC-Indole-2-Bpin; N-Boc-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)indole
EINECS	Contact for details

Quality Control

Our 1-Boc-Indole-2-Boronic Acid, Pinacol Ester is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity for sensitive coupling reactions. Each lot undergoes comprehensive analytical testing, including HPLC, NMR (1H, 13C, 11B), and mass spectrometry, to confirm identity and purity. Certificates of Analysis (COA) with full specification data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. The product is light-sensitive (store away from light) and should be allowed to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.