Description

4-(5,5-Dimethyl-[1,3,2]Dioxaborinan-2-Yl)-1-(Tetrahydropyran-2-Yl)-1H-Pyrazole is a high-value, protected boronic ester derivative, serving as a critical synthetic intermediate in modern organic chemistry. Its primary value lies in enabling efficient cross-coupling reactions, particularly the Suzuki-Miyaura reaction, which is fundamental for constructing complex molecular architectures. This compound is essential for research and development chemists in the pharmaceutical, agrochemical, and advanced materials sectors, where it is used to introduce the pyrazole-boronate moiety into target molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly in kinase inhibitor and anti-inflammatory research.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides that require the pyrazole heterocycle.
• Material Science Research: Serves as a precursor for creating functional organic molecules used in organic light-emitting diodes (OLEDs) and other electronic materials.
• Chemical Biology & Proteomics: Employed in the synthesis of chemical probes and affinity tags for studying biological systems and protein function.
• Custom Synthesis & Contract Manufacturing: A vital reagent for custom synthesis houses and CROs/CMOs producing specialized compounds for client projects.
• Academic Research: Used in university and institutional labs for methodological development in cross-coupling chemistry and heterocyclic compound synthesis.

Basic Information

Item	Details
Product Name	4-(5,5-Dimethyl-[1,3,2]Dioxaborinan-2-Yl)-1-(Tetrahydropyran-2-Yl)-1H-Pyrazole
CAS No.	1072944-26-3
Molecular Formula	C13H21BN2O3
Molecular Weight	264.13 g/mol
Synonyms	4-(5,5-Dimethyl-1,3,2-dioxaborinan-2-yl)-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazole; 1-(Oxan-2-yl)-4-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)pyrazole; 4-(5,5-Dimethyl-1,3,2-dioxaborinan-2-yl)-1-(tetrahydropyran-2-yl)-1H-pyrazole; THP-Protected Pyrazole Boronic Ester; 1-(Tetrahydro-2H-pyran-2-yl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole (Isomeric/Related); Pyrazole Boronate Ester; CAS 1072944-26-3.
EINECS	Contact for details

Quality Control

Our production of 4-(5,5-Dimethyl-[1,3,2]Dioxaborinan-2-Yl)-1-(Tetrahydropyran-2-Yl)-1H-Pyrazole adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Products undergo rigorous analytical testing, including HPLC, NMR (¹H and ¹³C), and mass spectrometry, to confirm identity and quantify purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and when dispensing to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.