Description

5-Bromo-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine is a high-value, multi-functional heterocyclic boronic ester derivative that serves as a critical building block in modern synthetic chemistry. Its primary commercial value lies in enabling efficient cross-coupling reactions, which are fundamental for constructing complex molecular architectures. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors, particularly for developing novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, especially kinase inhibitors and other targeted therapies.
• Agrochemical Research: Used in the discovery and development of new herbicides, fungicides, and insecticides with improved efficacy and selectivity.
• Material Science: Serves as a monomer or functional unit in the synthesis of organic electronic materials, such as those used in OLEDs and organic semiconductors.
• Chemical Biology & Proteomics: Employed as a versatile handle for bioconjugation and the development of molecular probes and activity-based protein profiling (ABPP) reagents.
• Academic & Contract Research: A valuable reagent for methodology development and exploring new synthetic pathways in organic and medicinal chemistry laboratories.
• Scale-up Synthesis: Supplied in commercial quantities to support process development and pilot-scale manufacturing of target molecules.

Basic Information

Product Name	5-Bromo-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine
CAS No.	1072152-50-1
Molecular Formula	C13H16BBrN2O2
Molecular Weight	323.00 g/mol
Synonyms	5-Bromo-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine; 5-Bromo-3-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine; 5-Bromo-3-(pinacolatoboryl)-1H-pyrrolo[2,3-b]pyridine; 5-Bromo-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-7-azaindole; 5-Bromo-3-boronic acid pinacol ester-1H-pyrrolo[2,3-b]pyridine; 1H-Pyrrolo[2,3-b]pyridine, 5-bromo-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; 5-Bromo-3-(pinacolboron)-1H-pyrrolo[2,3-b]pyridine
EINECS	Contact for details

Quality Control

Our 5-Bromo-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine is manufactured under strict quality management systems to ensure batch-to-batch consistency and reliability for your critical synthesis. Each lot undergoes comprehensive analytical characterization, including HPLC, NMR, and MS, to verify identity and purity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support development and regulatory needs with material produced under cGMP guidelines upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Single Unknown Impurity (HPLC)	≤1.0%
Total Impurities (HPLC)	≤3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.