Description

4-Chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine is a high-purity, advanced pharmaceutical intermediate featuring a protected boronic ester functional group. This compound is a critical building block in modern medicinal chemistry, enabling efficient cross-coupling reactions for the synthesis of complex heterocyclic molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel small-molecule therapeutics, particularly in oncology and CNS drug discovery.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a key electrophilic partner for constructing biaryl and heterobiaryl systems in drug candidates.
• Pharmaceutical Intermediate: A versatile building block for synthesizing active pharmaceutical ingredients (APIs) and preclinical drug candidates.
• Proteolysis Targeting Chimera (PROTAC) Development: Used in the synthesis of heterobifunctional molecules that target proteins for degradation.
• Kinase Inhibitor Synthesis: Integral to the construction of core scaffolds for kinase inhibitors, a major class of oncology drugs.
• Chemical Biology Probes: Enables the creation of tagged molecules for studying biological pathways and target engagement.
• Agrochemical Research: Employed in the discovery of new active ingredients with novel modes of action.
• Material Science: Potential precursor for organic electronic materials and metal-organic frameworks (MOFs).

Basic Information

Product Name	4-Chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine
CAS No.	1072145-24-4
Molecular Formula	C13H16BClN2O2
Molecular Weight	278.54 g/mol
Synonyms	4-Chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine; 4-Chloro-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)-7-azaindole; 4-Chloro-5-(pinacolboryl)-1H-pyrrolo[2,3-b]pyridine; 4-Chloro-5-(pinacolatoboryl)-1H-pyrrolo[2,3-b]pyridine; 4-Chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine; 1H-Pyrrolo[2,3-b]pyridine, 4-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; 4-Chloro-5-(pinacol boronate)-7-azaindole
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Each batch is characterized using advanced analytical techniques to guarantee identity, purity, and consistency. We adhere to strict in-house specifications and can provide material suitable for research and development under cGMP guidelines. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C in a dry, cool environment. Due to its hygroscopic and easily oxidized nature, prolonged exposure to air, moisture, or elevated temperatures should be avoided to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.