Description

1-[[2-(Trimethylsilyl)Ethoxy]Methyl]-1H-Pyrrolo[2,3-B]Pyridin-5-Boronic Acid, Pinacol Ester is a sophisticated, protected boronic acid ester derivative, a critical building block in modern synthetic chemistry. Its primary value lies in enabling efficient cross-coupling reactions, specifically Suzuki-Miyaura couplings, for constructing complex heterocyclic scaffolds. This high-purity intermediate is essential for researchers and process chemists in pharmaceutical R&D and agrochemical synthesis, where it facilitates the creation of novel active compounds.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in kinase inhibitor and other small-molecule therapeutic programs.
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a stable, protected boronic ester reagent for palladium-catalyzed carbon-carbon bond formation under mild conditions.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides requiring specific heterocyclic architectures.
• Material Science Research: Employed in the creation of organic electronic materials and functional polymers with tailored properties.
• Chemical Biology & Proteolysis Targeting Chimeras (PROTACs): A valuable linker or component in the design of bifunctional molecules for targeted protein degradation.
• Scale-Up Process Development: Suitable for process optimization and kilogram-scale production of target molecules in pilot plants.

Basic Information

Item	Detail
Product Name	1-[[2-(Trimethylsilyl)Ethoxy]Methyl]-1H-Pyrrolo[2,3-B]Pyridin-5-Boronic Acid, Pinacol Ester
CAS No.	1071454-83-5
Molecular Formula	C18H31BN2O3Si
Molecular Weight	362.35 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-[[2-(trimethylsilyl)ethoxy]methyl]-1H-pyrrolo[2,3-b]pyridine; 1-((2-(Trimethylsilyl)ethoxy)methyl)-1H-pyrrolo[2,3-b]pyridine-5-boronic acid pinacol ester; 1H-Pyrrolo[2,3-b]pyridine-5-boronic acid, 1-[[2-(trimethylsilyl)ethoxy]methyl]-, 1,1-dimethylethyl ester; SEM-Protected 5-Boronic Acid Pinacol Ester of 7-Azaindole; 5-Borono-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrrolo[2,3-b]pyridine pinacol ester
EINECS	Contact for details

Quality Control

Our 1-[[2-(Trimethylsilyl)Ethoxy]Methyl]-1H-Pyrrolo[2,3-B]Pyridin-5-Boronic Acid, Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) with full analytical data are provided to guarantee compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C or as specified on the label or COA. This compound is easily oxidized and light-sensitive; prolonged exposure to air, moisture, or light should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.