Description

3-Bromo-5-Chloroisonicotinaldehyde is a high-purity halogenated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its unique bifunctional structure, featuring both bromo and chloro substituents adjacent to an aldehyde group, makes it an indispensable intermediate for constructing complex molecular architectures. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potential drug candidates, particularly in kinase inhibitor and antiviral research programs.
• Agrochemical Synthesis: Used to construct novel pyridine-based herbicides, fungicides, and insecticides with tailored activity profiles.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized chelating ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the development of organic electronic materials, such as ligands for OLEDs or molecular sensors.
• Cross-Coupling Reactions: The bromo substituent is an excellent handle for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to create biaryl systems.
• Chemical Biology Probes: Used to synthesize tagged molecules or photoaffinity labels for studying biological pathways and target engagement.

Basic Information

Product Name	3-Bromo-5-Chloroisonicotinaldehyde
CAS No.	1064678-66-5
Molecular Formula	C6H3BrClNO
Molecular Weight	220.45 g/mol
Synonyms	5-Bromo-3-Chloro-4-pyridinecarboxaldehyde; 3-Bromo-5-chloropyridine-4-carbaldehyde; 4-Pyridinecarboxaldehyde, 3-bromo-5-chloro-; 3-Bromo-5-chloroisonicotinaldehyde; Isonicotinaldehyde, 3-bromo-5-chloro-
EINECS	Contact for details

Quality Control

Our 3-Bromo-5-Chloroisonicotinaldehyde is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical characterization, including HPLC for purity, NMR for structural confirmation, and GC-MS for solvent residue analysis, to ensure it meets the stringent requirements of research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This compound is easily oxidized and should be handled under an inert atmosphere for long-term storage. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.