Description

3-Cyclopropylisonicotinaldehyde is a versatile and high-value heterocyclic building block, specifically a functionalized pyridine derivative, essential for advanced organic synthesis. Its core value lies in the strategic combination of the cyclopropyl group and the aldehyde functionality on the isonicotinaldehyde scaffold, enabling the construction of complex molecular architectures. This compound is critically needed by pharmaceutical, agrochemical, and material science research and development teams for applications in medicinal chemistry, catalyst development, and the synthesis of novel ligands.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, infectious diseases, and oncology.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, leveraging the bioactivity of the pyridine and cyclopropane motifs.
• Ligand and Catalyst Development: Serves as a crucial building block for creating novel chelating ligands, organocatalysts, and metal-organic frameworks (MOFs) in material science.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes and inhibitors for studying enzyme function and biological pathways.
• Cross-Coupling Reactions: The aldehyde group is a versatile handle for further transformations, including reductive amination, condensation, and participation in palladium-catalyzed cross-coupling reactions.
• Fine Chemical and Specialty Chemical Production: Integral to the multi-step synthesis of complex, high-value fine chemicals for various industrial and research applications.

Basic Information

Item	Detail
Product Name	3-Cyclopropylisonicotinaldehyde
CAS No.	1063960-86-0
Molecular Formula	C9H9NO
Molecular Weight	147.17 g/mol
Synonyms	3-Cyclopropyl-4-pyridinecarboxaldehyde; 3-Cyclopropylpyridine-4-carbaldehyde; 4-Pyridinecarboxaldehyde, 3-cyclopropyl-; Isonicotinaldehyde, 3-cyclopropyl-; 3-Cyclopropyl-isonicotinaldehyde; 3-Cyclopropyl-4-formylpyridine; 3-Cyclopropyl-4-pyridylcarboxaldehyde
EINECS	Contact for details

Quality Control

Our 3-Cyclopropylisonicotinaldehyde is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment to quality supports compliance with cGMP and ICH guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is easily oxidized (store under inert atmosphere) and is light-sensitive (store away from light). For long-term storage, consider storage under an inert gas such as nitrogen or argon.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Standard Grade)
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.