Description

(1R,4R,7R)-7-Isopropyl-2-(1-Hydroxy-1-Methylethyl)-5-Methylbicyclo[2.2.2]Octa-2,5-Diene is a high-purity, stereochemically defined bicyclic diene compound that serves as a critical advanced pharmaceutical intermediate (API) and a versatile chiral building block in complex organic synthesis. Its unique, rigid molecular framework and specific stereochemistry make it invaluable for constructing complex natural product analogs and bioactive molecules with precise three-dimensional architectures. This compound is essential for R&D and production teams in the pharmaceutical, agrochemical, and specialty fine chemical sectors seeking reliable, high-quality chiral intermediates.

Application

• Pharmaceutical Intermediate: Key chiral precursor in the synthesis of novel therapeutic agents, particularly for central nervous system (CNS) and anti-inflammatory targets.
• Asymmetric Catalysis: Employed as a ligand or a core scaffold in the development of chiral catalysts for enantioselective transformations.
• Natural Product Synthesis: Crucial building block for the total synthesis of complex terpenoids and other natural products with bicyclo[2.2.2]octane cores.
• Agrochemical Research: Used in developing new generations of chiral pesticides and herbicides with improved efficacy and environmental profiles.
• Material Science: Serves as a monomer or cross-linking agent for creating novel polymers with specific thermal and mechanical properties.
• Flavor & Fragrance Chemistry: Intermediate for synthesizing high-value aroma chemicals with complex, woody, or amber notes.

Basic Information

Item	Details
Product Name	(1R,4R,7R)-7-Isopropyl-2-(1-Hydroxy-1-Methylethyl)-5-Methylbicyclo[2.2.2]Octa-2,5-Diene
CAS No.	1063949-39-2
Molecular Formula	C15H24O
Molecular Weight	220.35 g/mol
Synonyms	(1R,4R,7R)-7-Isopropyl-2-(2-hydroxypropan-2-yl)-5-methylbicyclo[2.2.2]octa-2,5-diene; (1R,4R,7R)-2-(1-Hydroxy-1-methylethyl)-7-isopropyl-5-methylbicyclo[2.2.2]octa-2,5-diene; Bicyclo[2.2.2]octa-2,5-diene-2-ethanol, 7-isopropyl-5-methyl-, (1R,4R,7R)-; Chiral Bicyclic Diene Intermediate; (+)-Isomer of the specified diene.
EINECS	Contact for details

Quality Control

Every batch of our (1R,4R,7R)-7-Isopropyl-2-(1-Hydroxy-1-Methylethyl)-5-Methylbicyclo[2.2.2]Octa-2,5-Diene is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and stereochemical integrity. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes data from chiral HPLC, NMR, and GC/MS analysis. Our quality commitment aligns with cGMP principles for advanced intermediates, ensuring traceability and consistency for critical pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.