Description

(R)-Boro-N(Ethyl)-Gly-(+)-Pinanediol-Hcl CAS NO 1063700-88-8 is a high-purity, chiral boronic acid derivative used as a critical building block in advanced organic synthesis. This compound matters for its role in facilitating stereoselective carbon-carbon bond formation, a cornerstone of modern pharmaceutical and agrochemical research. It is essential for medicinal chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries who require reliable, high-quality intermediates for the synthesis of complex, biologically active molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel active pharmaceutical ingredients (APIs), particularly for protease inhibitors and other targeted therapies.
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a sophisticated boronic ester reagent for the palladium-catalyzed formation of C-C bonds under mild conditions, enabling the construction of complex biaryl structures.
• Peptidomimetic Synthesis: Used in the design and synthesis of peptide analogs and peptidomimetics to enhance metabolic stability and bioavailability.
• Agrochemical Research: Employed as a building block in the development of new, more effective herbicides and insecticides with chiral centers.
• Asymmetric Synthesis Catalysis: Can be utilized in the preparation of chiral ligands or catalysts for enantioselective transformations.
• Chemical Biology Probes: Acts as a versatile handle for bioconjugation and the development of activity-based probes for studying enzyme function.

Basic Information

Product Name	(R)-Boro-N(Ethyl)-Gly-(+)-Pinanediol-Hcl
CAS No.	1063700-88-8
Molecular Formula	C₁₅H₂₇BNO₃ • HCl
Molecular Weight	307.66 g/mol (Free base: 271.19 g/mol)
Synonyms	(R)-N-Ethyl-2-((3aR,4S,6R,6aR)-2,2-dimethyltetrahydro-3aH-[1,3]dioxolo[4,5-c]pyrrol-4-yl)acetamido)ethylboronic Acid Pinanediol Ester Hydrochloride; (R)-Boro-N-Ethyl-Glycine Pinanediol Ester Hydrochloride; (R)-Boro-N(Et)-Gly-Pinanediol-HCl; N-((R)-2-Borono-1-ethyl-2-((3aR,4S,6R,6aR)-2,2-dimethyltetrahydro-3aH-[1,3]dioxolo[4,5-c]pyrrol-4-yl)ethyl)acetamide Pinanediol Ester Hydrochloride; (R)-Boro-N-Ethyl-Gly-(+)-Pinanediol Hydrochloride
EINECS	Contact for details

Quality Control

Our (R)-Boro-N(Ethyl)-Gly-(+)-Pinanediol-Hcl is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research and development applications. Each lot undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to meet exacting customer specifications. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (argon or nitrogen) when possible to maintain stability and purity. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.