Description

5-(Trifluoromethoxy)Nicotinic Acid is a high-value fluorinated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its unique trifluoromethoxy-substituted nicotinic acid structure offers enhanced metabolic stability and lipophilicity, making it indispensable for developing novel active compounds. This intermediate is primarily sought by pharmaceutical and agrochemical R&D teams for the creation of next-generation products.

Application

• Pharmaceutical Intermediate: Key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and central nervous system (CNS) drug discovery.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and fungicides, where the trifluoromethoxy group imparts improved biological activity and environmental persistence.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organocatalysis.
• Material Science Research: Employed in the synthesis of functionalized polymers and advanced organic materials with specific electronic properties.
• Chemical Biology Probes: Utilized to create fluorinated analogs for studying biochemical pathways and protein-ligand interactions.

Basic Information

Product Name	5-(Trifluoromethoxy)Nicotinic Acid
CAS No.	1060815-03-3
Molecular Formula	C7H4F3NO3
Molecular Weight	207.11 g/mol
Synonyms	5-(Trifluoromethoxy)pyridine-3-carboxylic acid; Nicotinic acid, 5-(trifluoromethoxy)-; 3-Pyridinecarboxylic acid, 5-(trifluoromethoxy)-; 5-Trifluoromethoxynicotinic acid; 5-(Trifluoromethoxy)nicotinate
EINECS	Contact for details

Quality Control

Our production of 5-(Trifluoromethoxy)Nicotinic Acid adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.