Description

6-Chloro-4-Fluoronicotinaldehyde is a versatile and high-value fluorinated pyridine derivative, serving as a critical building block in modern synthetic chemistry. Its core value lies in the reactive aldehyde group and halogenated pyridine scaffold, enabling precise molecular construction for advanced applications. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, where it is used to synthesize novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, leveraging the fluoropyridine motif for enhanced bioactivity.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands and organocatalysts used in asymmetric synthesis and cross-coupling reactions.
• Material Science Research: Employed in the synthesis of functionalized organic molecules for electronic materials, liquid crystals, and advanced polymers.
• Custom Synthesis & Contract Manufacturing: A fundamental building block for custom synthesis projects and scale-up processes in fine chemical production.

Basic Information

Product Name	6-Chloro-4-Fluoronicotinaldehyde
CAS No.	1060809-20-2
Molecular Formula	C6H3ClFNO
Molecular Weight	159.55 g/mol
Synonyms	4-Fluoro-6-chloronicotinaldehyde; 6-Chloro-4-fluoropyridine-3-carboxaldehyde; 3-Pyridinecarboxaldehyde, 6-chloro-4-fluoro-; 6-Chloro-4-fluoro-3-formylpyridine; 6-Chloro-4-fluoronicotinaldehyde; 1060809-20-2; 6-Chloro-4-fluoro-3-pyridinecarboxaldehyde
EINECS	Contact for details

Quality Control

Our 6-Chloro-4-Fluoronicotinaldehyde is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all specifications and test results. Our quality commitment supports compliance with cGMP and ICH guidelines for advanced intermediate synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry place at 2-8°C to minimize oxidation and degradation. Keep away from strong oxidizing agents and bases. Allow the container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.