Description

4-Chloro-6-(Trifluoromethyl)Pyridine-3-Carboxaldehyde, also known as 4-Chloro-5-Formyl-2-(Trifluoromethyl)Pyridine, is a high-value, multi-functional pyridine derivative that serves as a critical advanced intermediate in modern synthetic chemistry. Its molecular structure, featuring both a reactive aldehyde group and a chloro-trifluoromethyl substituted pyridine ring, makes it an indispensable building block for constructing complex molecules with tailored properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of drugs targeting the central nervous system, anti-infectives, and oncology therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides, herbicides, and fungicides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of organic electronic materials, such as charge-transport layers or fluorescent dyes.
• Custom Synthesis and Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.

Basic Information

Product Name	4-Chloro-6-(Trifluoromethyl)Pyridine-3-Carboxaldehyde, 4-Chloro-5-Formyl-2-(Trifluoromethyl)Pyridine
CAS No.	1060807-48-8
Molecular Formula	C7H3ClF3NO
Molecular Weight	209.55 g/mol
Synonyms	4-Chloro-6-(trifluoromethyl)nicotinaldehyde; 4-Chloro-5-formyl-2-(trifluoromethyl)pyridine; 4-Chloro-2-(trifluoromethyl)pyridine-5-carboxaldehyde; 5-Formyl-4-chloro-2-(trifluoromethyl)pyridine; 3-Formyl-4-chloro-6-(trifluoromethyl)pyridine; 4-Chloro-6-trifluoromethyl-pyridine-3-carbaldehyde; 1060807-48-8
EINECS	Contact for details

Quality Control

Our production of 4-Chloro-6-(Trifluoromethyl)Pyridine-3-Carboxaldehyde adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, documenting critical parameters such as assay and impurity profiles. Our quality systems are designed to support cGMP compliance for pharmaceutical applications and meet the exacting standards required for global regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is easily oxidized and should be handled under an inert atmosphere for long-term storage or when opening sealed containers. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.