Description

2,2,2-Trifluoro-1-(5-Hydroxy-Pyridin-3-Yl)-Ethanone is a high-purity fluorinated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its unique trifluoroacetyl and hydroxypyridine structure makes it an invaluable intermediate for developing novel active pharmaceutical ingredients (APIs) and agrochemicals. This compound is essential for research and development chemists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce fluorine atoms for enhanced metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of fluorinated drug candidates, particularly in oncology, central nervous system (CNS), and anti-infective therapeutic areas.
• Agrochemical Research: Used in the development of new-generation herbicides, fungicides, and insecticides where the trifluoromethyl group improves efficacy and environmental profile.
• Ligand & Catalyst Development: Serves as a precursor for creating novel chelating ligands and organocatalysts used in asymmetric synthesis and metal complexation.
• Material Science: Employed in the research of advanced polymers and organic electronic materials that require fluorinated aromatic components.
• Chemical Biology Probes: Utilized as a building block for synthesizing fluorescent tags or molecular probes for studying biological systems.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis projects and scale-up processes under GMP or non-GMP conditions.

Basic Information

Product Name	2,2,2-Trifluoro-1-(5-Hydroxy-Pyridin-3-Yl)-Ethanone
CAS No.	1060804-64-9
Molecular Formula	C7H4F3NO2
Molecular Weight	191.11 g/mol
Synonyms	1-(5-Hydroxypyridin-3-yl)-2,2,2-trifluoroethanone; 3-Acetyl-5-hydroxypyridine, 2,2,2-trifluoro-; 5-Hydroxy-3-pyridinyl trifluoromethyl ketone; 2,2,2-Trifluoro-1-(5-hydroxypyridin-3-yl)ethan-1-one; 3-(Trifluoroacetyl)-5-hydroxypyridine; 5-Hydroxy-3-trifluoroacetylpyridine; Trifluoro(5-hydroxy-3-pyridinyl)methanone
EINECS	Contact for details

Quality Control

Our 2,2,2-Trifluoro-1-(5-Hydroxy-Pyridin-3-Yl)-Ethanone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with ISO 9001 standards, and we can support development projects requiring documentation for regulatory filings (e.g., DMF, CMC).

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.