Description

4-Chloro-5-Fluoronicotinaldehyde is a high-value fluorinated and chlorinated pyridine derivative, serving as a critical advanced intermediate in modern synthetic chemistry. Its unique halogenated structure makes it an essential building block for constructing complex molecules with tailored properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting central nervous system (CNS) disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the research and development of new-generation herbicides, fungicides, and insecticides, where the fluorine and chlorine atoms enhance biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands and organocatalysts used in asymmetric synthesis and cross-coupling reactions.
• Material Science Research: Employed in the development of organic electronic materials, such as semiconductors and light-emitting diodes (OLEDs), due to its electron-withdrawing characteristics.
• Custom Synthesis and Contract Manufacturing: A vital substrate for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) working on client-specific molecular entities.

Basic Information

Product Name	4-Chloro-5-Fluoronicotinaldehyde
CAS No.	1060802-34-7
Molecular Formula	C6H3ClFNO
Molecular Weight	159.55 g/mol
Synonyms	5-Fluoro-4-chloropyridine-3-carboxaldehyde; 3-Formyl-4-chloro-5-fluoropyridine; 4-Chloro-5-fluoro-3-pyridinecarboxaldehyde; 4-Chloro-5-fluoronicotinaldehyde; 4-Chloro-5-fluoropyridine-3-carbaldehyde; Nicotinaldehyde, 4-chloro-5-fluoro-; 3-Pyridinecarboxaldehyde, 4-chloro-5-fluoro-
EINECS	Contact for details

Quality Control

Our 4-Chloro-5-Fluoronicotinaldehyde is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed specifications. We support cGMP (current Good Manufacturing Practice) standards for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive and should be stored away from light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.