Description

Benzene, 2-Chloro-1-Ethynyl-4-Fluoro- is a specialized halogenated aromatic building block of significant interest in advanced organic synthesis. Its unique structure, featuring both chloro, fluoro, and ethynyl substituents, makes it a valuable precursor for constructing complex molecular architectures. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the research and development of novel drug candidates, particularly in medicinal chemistry programs targeting selective enzyme inhibitors or receptor modulators.
• Agrochemical Synthesis: Used in the creation of advanced pesticide and herbicide molecules, where the introduction of fluorine and chlorine atoms can enhance biological activity and environmental stability.
• Material Science Research: Acts as a monomer or functionalization agent in the development of specialty polymers, liquid crystals, or organic electronic materials due to its conjugated ethynyl group.
• Chemical Biology Probes: Employed in the synthesis of tagged molecules or probes for studying biological processes, leveraging its reactive alkyne group for click chemistry applications.
• Cross-Coupling Reactions: Functions as a substrate in palladium-catalyzed reactions (e.g., Sonogashira, Suzuki-Miyaura) to create complex biaryl or conjugated systems.

Basic Information

Product Name	Benzene, 2-Chloro-1-Ethynyl-4-Fluoro-
CAS No.	1057670-02-6
Molecular Formula	C8H4ClF
Molecular Weight	154.57 g/mol
Synonyms	2-Chloro-1-ethynyl-4-fluorobenzene; 1-Chloro-2-ethynyl-5-fluorobenzene; 4-Fluoro-2-chlorophenylacetylene; 2-Chloro-4-fluorophenylacetylene; 5-Fluoro-2-chlorophenylacetylene; (2-Chloro-4-fluorophenyl)ethyne
EINECS	Contact for details

Quality Control

Every batch of Benzene, 2-Chloro-1-Ethynyl-4-Fluoro- is produced and tested under strict quality management protocols to ensure consistency and reliability for research and development applications. We employ advanced analytical techniques including GC, HPLC, and NMR to verify identity, purity, and the absence of critical impurities. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). Keep away from heat, sparks, and open flames. Due to its light-sensitive nature, containers should be kept in amber glass or opaque packaging during storage.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.