Description

1-Bromo-3-(Chloromethyl)-5-Methylbenzene is a versatile halogenated aromatic building block of significant importance in advanced organic synthesis. Its bifunctional nature, featuring both bromine and chloromethyl reactive sites, makes it a critical intermediate for constructing complex molecular architectures. This compound is primarily utilized by research institutions and industrial R&D departments in the pharmaceutical and agrochemical sectors for the development of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), especially in the development of novel small-molecule drugs.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, leveraging its aromatic halogen structure.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized phosphine ligands, N-heterocyclic carbenes (NHCs), and other organometallic catalysts.
• Material Science Monomer: Employed in the synthesis of specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: An essential substrate for Suzuki, Heck, and Buchwald-Hartwig amination reactions to form biaryl and complex aromatic systems.
• Chemical Research & Development: A valuable reagent for exploring new synthetic methodologies and creating compound libraries for high-throughput screening.

Basic Information

Product Name	1-Bromo-3-(Chloromethyl)-5-Methylbenzene
CAS No.	1056893-13-0
Molecular Formula	C8H8BrCl
Molecular Weight	219.51 g/mol
Synonyms	3-Bromo-5-(chloromethyl)toluene; 5-Bromo-3-(chloromethyl)toluene; 1-Bromo-3-(chloromethyl)-5-methyl-benzene; 3-Methyl-5-bromobenzyl chloride; (3-Bromo-5-methylphenyl)methyl chloride; 5-Bromo-m-xylene-α-chloride; Toluene, 3-bromo-5-(chloromethyl)-; Benzene, 1-bromo-3-(chloromethyl)-5-methyl-
EINECS	Contact for details

Quality Control

Our 1-Bromo-3-(Chloromethyl)-5-Methylbenzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to guarantee compliance with your research and production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC/GC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	< 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.