Description

2-(3-Bromo-5-Chlorophenyl)Acetonitrile is a versatile halogenated aromatic nitrile building block of significant interest in advanced organic synthesis. Its molecular structure, featuring both bromo and chloro substituents on the phenyl ring, makes it a critical intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of active pharmaceutical ingredients (APIs) and novel crop protection agents.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting CNS disorders and oncology.
• Agrochemical Synthesis: Serves as a precursor in the development of new herbicides, fungicides, and insecticides, leveraging its halogenated phenyl core.
• Ligand and Catalyst Development: Used to create specialized ligands for transition metal catalysis and organocatalysts due to its modifiable nitrile and halogen functional groups.
• Material Science Research: Employed in the synthesis of organic semiconductors, liquid crystals, and advanced polymers where specific halogen interactions are required.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and Buchwald-Hartwig amination reactions, enabling rapid diversification of chemical space.
• Chemical Biology Probes: Useful for synthesizing tagged molecules and activity-based probes for studying biological pathways and target engagement.

Basic Information

Product Name	2-(3-Bromo-5-Chlorophenyl)Acetonitrile
CAS No.	1056454-88-6
Molecular Formula	C8H5BrClN
Molecular Weight	230.49 g/mol
Synonyms	(3-Bromo-5-chlorophenyl)acetonitrile; 2-(3-Bromo-5-chlorophenyl)ethanenitrile; 3-Bromo-5-chlorobenzyl cyanide; 3-Bromo-5-chlorophenylacetonitrile; α-Cyano-3-bromo-5-chlorotoluene; (3-Bromo-5-chloro-benzyl)-cyanide; 1056454-88-6; Benzeneacetonitrile, 3-bromo-5-chloro-
EINECS	Contact for details

Quality Control

Our 2-(3-Bromo-5-Chlorophenyl)Acetonitrile is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with customer specifications and internal quality standards. Our commitment to traceability and documentation supports cGMP and ISO 9001 requirements for critical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents, strong bases, and sources of ignition. The compound may be light-sensitive; prolonged exposure to light should be avoided.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.