Description

2-Chloro-9-Isopropyl-n-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)-9H-Purin-6-Amine is a high-value, advanced pharmaceutical intermediate and building block designed for modern synthetic chemistry. This compound matters because it integrates a purine core with a versatile pinacol boronate ester, enabling critical cross-coupling reactions like the Suzuki-Miyaura reaction for constructing complex molecules. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, particularly in oncology and antiviral drug discovery programs.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of targeted small molecule drugs, especially kinase inhibitors and nucleotide analogs.
• Suzuki-Miyaura Cross-Coupling: The boronate ester functional group makes it an ideal reagent for palladium-catalyzed C-C bond formation to create biaryl structures.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new active pharmaceutical ingredients (APIs).
• Chemical Biology Probes: Serves as a precursor for creating labeled compounds or probes to study biological pathways and target engagement.
• Process Chemistry Development: Employed in scaling up synthetic routes for potential drug candidates during preclinical and clinical development phases.

Basic Information

Product Name	2-Chloro-9-Isopropyl-n-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)-9H-Purin-6-Amine
CAS No.	1056016-74-0
Molecular Formula	C20H25BClN5O2
Molecular Weight	405.71 g/mol
Synonyms	2-Chloro-9-isopropyl-N-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-9H-purin-6-amine; 2-Chloro-9-isopropyl-N-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-9H-purin-6-amine; 9H-Purin-6-amine, 2-chloro-9-(1-methylethyl)-N-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-; 1056016-74-0; 2-Chloro-9-isopropylpurine-6-amine boronic acid pinacol ester; N-(4-Boronophenyl)-2-chloro-9-isopropyl-9H-purin-6-amine pinacol ester
EINECS	Contact for details

Quality Control

Our 2-Chloro-9-Isopropyl-n-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)-9H-Purin-6-Amine is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and LC-MS for identity verification, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to prevent degradation. For long-term storage, consider storing desiccated at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.