Description

4-Bromo-n-Cyclopropyl-2-Fluorobenzenesulfonamide is a high-purity, advanced pharmaceutical intermediate characterized by its unique halogenated cyclopropyl benzenesulfonamide structure. This compound is of significant value in medicinal chemistry for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting enzyme inhibition. It is primarily sought after by research institutions and pharmaceutical manufacturers engaged in the development of new therapeutic agents, where precise molecular architecture is critical.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of potential drug candidates, especially in oncology and central nervous system (CNS) therapeutic areas.
• Medicinal Chemistry Research: Used as a scaffold or building block for structure-activity relationship (SAR) studies to optimize potency and selectivity of lead compounds.
• Protease Inhibitor Development: The sulfonamide moiety makes it a valuable synthon for developing inhibitors of various enzymes like carbonic anhydrases or serine proteases.
• Agrochemical Synthesis: Serves as an intermediate in the research and development of new generation herbicides or fungicides with novel modes of action.
• Material Science Research: Potential use in the synthesis of specialized monomers for advanced polymers with specific electronic or structural properties.

Basic Information

Product Name	4-Bromo-n-Cyclopropyl-2-Fluorobenzenesulfonamide
CAS No.	1055995-89-5
Molecular Formula	C9H9BrFNO2S
Molecular Weight	294.14 g/mol
Synonyms	4-Bromo-N-cyclopropyl-2-fluorobenzenesulfonamide; 2-Fluoro-4-bromo-N-cyclopropylbenzenesulfonamide; Benzenesulfonamide, 4-bromo-N-cyclopropyl-2-fluoro-; 4-Bromo-2-fluoro-N-cyclopropylbenzenesulfonamide; 1055995-89-5; 4-Bromo-N-cyclopropyl-2-fluorobenzene-1-sulfonamide
EINECS	Contact for details

Quality Control

Every batch of 4-Bromo-n-Cyclopropyl-2-Fluorobenzenesulfonamide is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high standards required for pharmaceutical R&D and scale-up. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles by HPLC, NMR, and MS is supplied with each shipment, ensuring full traceability and compliance with your internal quality protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5% Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.