Description

4,4-Difluorocyclohexaneethanamine is a versatile fluorinated amine building block of significant interest in advanced organic synthesis. Its value lies in the unique combination of a rigid, fluorinated cyclohexyl scaffold with a flexible ethanamine linker, enabling precise modulation of molecular properties. This compound is primarily sought by researchers and process chemists in the pharmaceutical and agrochemical industries for the development of novel active ingredients, where it serves as a key intermediate for creating compounds with enhanced metabolic stability, bioavailability, and binding affinity.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and oncology research, where the difluorocyclohexyl group can improve lipophilicity and metabolic stability.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, where fluorine substitution is leveraged to enhance biological activity and environmental persistence.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands or organocatalysts in asymmetric synthesis, exploiting the amine functionality for metal coordination or as an active site.
• Material Science Research: Employed in the creation of specialty polymers, resins, or liquid crystals, where the fluorinated cyclic structure can impart unique thermal and chemical resistance properties.
• Chemical Biology Probe: Utilized as a scaffold or labeling agent in probe molecules for studying enzyme mechanisms or protein-ligand interactions due to its potential to act as a bioisostere.
• Custom Synthesis & Contract Manufacturing: A key starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	4,4-Difluorocyclohexaneethanamine
CAS No.	1054314-53-2
Molecular Formula	C8H15F2N
Molecular Weight	163.21 g/mol
Synonyms	2-(4,4-Difluorocyclohexyl)ethanamine; 4,4-Difluorocyclohexylethylamine; 2-(4,4-Difluorocyclohexyl)ethylamine; 4,4-Difluorocyclohexaneethylamine; 1-(2-Aminoethyl)-4,4-difluorocyclohexane; 4,4-Difluoro-1-cyclohexaneethanamine; 1054314-53-2; 4,4-Difluorocyclohexyl Ethyl Amine
EINECS	Contact for details

Quality Control

Our 4,4-Difluorocyclohexaneethanamine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment ensures the material is suitable for demanding applications in research and process development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.