Description

2-Methylpyrimidine-5-Boronic Acid Pinacol Ester is a high-purity boronic ester derivative, a crucial building block in modern synthetic organic chemistry. Its primary value lies in enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone method for constructing complex carbon-carbon bonds. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors, where it is used to synthesize novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and antiviral drug discovery programs.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides requiring specific pyrimidine-based structures.
• Material Science: Serves as a precursor for creating organic electronic materials, such as ligands for OLEDs and components for organic semiconductors.
• Chemical Research & Development: A versatile reagent in academic and industrial R&D labs for constructing complex heterocyclic compounds via palladium-catalyzed cross-coupling.
• Ligand Synthesis: Used to prepare specialized bidentate or tridentate ligands for catalysis and coordination chemistry.
• Library Synthesis: Employed in parallel and combinatorial chemistry to generate diverse compound libraries for high-throughput screening.

Basic Information

Product Name	2-Methylpyrimidine-5-Boronic Acid Pinacol Ester
CAS No.	1052686-67-5
Molecular Formula	C11H17BN2O2
Molecular Weight	220.08 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-methylpyrimidine; 2-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine; 2-Methylpyrimidin-5-ylboronic acid pinacol ester; (2-Methylpyrimidin-5-yl)boronic acid pinacol ester; Pinacol 2-Methylpyrimidine-5-boronate; 5-Borono-2-methylpyrimidine pinacol ester; CAS 1052686-67-5
EINECS	Contact for details

Quality Control

Our 2-Methylpyrimidine-5-Boronic Acid Pinacol Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, typically >97% (by HPLC). Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP guidelines where applicable, and our quality management system supports compliance with global regulatory standards for advanced chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.