Description

2-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine is a high-purity, advanced pharmaceutical intermediate and a versatile boronic ester building block. Its core value lies in enabling efficient Suzuki-Miyaura cross-coupling reactions, a critical step in constructing complex molecules for active pharmaceutical ingredients (APIs). This compound is essential for R&D and production teams in the pharmaceutical, agrochemical, and advanced materials sectors seeking to develop novel small-molecule therapeutics and functional chemicals.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in oncology, antiviral, and central nervous system (CNS) drug candidates.
• Suzuki-Miyaura Cross-Coupling: Serves as a stable, air-tolerant boronic ester reagent for palladium-catalyzed carbon-carbon bond formation with aryl/heteroaryl halides.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides requiring specific pyrimidine-based structures.
• Material Science Research: A precursor for creating organic electronic materials, such as ligands for OLEDs or molecular components for organic semiconductors.
• Chemical Biology & Medicinal Chemistry: Employed in fragment-based drug discovery and the synthesis of chemical probes for target validation.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP or research-grade conditions.

Basic Information

Product Name	2-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine
CAS No.	1052686-60-8
Molecular Formula	C11H17BN2O3
Molecular Weight	236.08 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-methoxypyrimidine; 2-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine; 2-Methoxypyrimidine-5-boronic acid pinacol ester; 5-(2-Methoxypyrimidin-5-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; Pyrimidine, 2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; 2-Methoxy-5-pyrimidinylboronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 2-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) with detailed specifications are provided for each lot. We support development and commercial projects with material suitable for research use and can supply grades aligned with ICH Q7 and cGMP principles for advanced pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.