Description

(Trans)-4-Phenyl-Pyrrolidine-3-Carboxylic Acid-Hcl CAS NO 1049755-65-8 is a high-purity chiral building block and pharmaceutical intermediate of significant commercial interest. Its rigid pyrrolidine scaffold and carboxylic acid functionality make it a versatile synthon for constructing complex molecules with defined stereochemistry. This compound is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas targeting the central nervous system.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of potential drug candidates, especially for neurological and psychiatric disorders.
• Asymmetric Synthesis Building Block: Utilized in medicinal chemistry for constructing complex, stereochemically defined molecular architectures.
• Chemical Research & Development: Serves as a critical reagent in academic and industrial R&D for exploring new synthetic pathways and bioactive compounds.
• Ligand and Catalyst Development: Used in the preparation of novel chiral ligands and organocatalysts for asymmetric transformations.
• Reference Standard: Employed as an analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	(Trans)-4-Phenyl-Pyrrolidine-3-Carboxylic Acid Hydrochloride
CAS No.	1049755-65-8
Molecular Formula	C11H13NO2 • HCl
Molecular Weight	227.69 g/mol
Synonyms	(3R,4S)-4-Phenylpyrrolidine-3-carboxylic acid hydrochloride; trans-4-Phenyl-3-pyrrolidinecarboxylic acid hydrochloride; (3R,4S)-1-Azabicyclo[3.2.0]heptane-3-carboxylic acid, 4-phenyl-, hydrochloride; 4-Phenyl-DL-proline hydrochloride (trans isomer); 1049755-65-8; (3R,4S)-4-Phenylpyrrolidine-3-carboxylic acid HCl salt
EINECS	Contact for details

Quality Control

Our (Trans)-4-Phenyl-Pyrrolidine-3-Carboxylic Acid-Hcl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and chiral purity analysis, to ensure it meets the high standards required for pharmaceutical research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and specification compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent moisture absorption. Recommended storage temperature is 2-8°C for extended stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.