Description

4-(Trifluoromethyl)Phenylglyoxal Hydrate is a high-value fluorinated aromatic building block, specifically a glyoxal hydrate derivative. This compound is prized for its trifluoromethyl group, which imparts unique electronic and lipophilic properties critical for advanced material and pharmaceutical synthesis. It serves as a versatile precursor for researchers and manufacturers in pharmaceutical development, agrochemical research, and the creation of specialty chemicals and functional materials.

Application

• Pharmaceutical Intermediate: Key synthon for the development of active pharmaceutical ingredients (APIs), particularly those targeting CNS and metabolic diseases where the CF₃ group enhances bioavailability and metabolic stability.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides, leveraging the trifluoromethyl moiety for improved efficacy and environmental profile.
• Ligand and Catalyst Development: Serves as a precursor for creating novel ligands and organocatalysts used in asymmetric synthesis and cross-coupling reactions.
• Material Science Research: Building block for synthesizing fluorinated polymers, liquid crystals, and organic electronic materials that require specific dielectric and surface properties.
• Chemical Biology Probes: Utilized in the design of activity-based probes and fluorogenic substrates for enzyme studies and diagnostic assays.
• Custom Synthesis and R&D: Essential for contract research organizations (CROs) and fine chemical companies engaged in custom synthesis and process development for novel chemical entities.

Basic Information

Product Name	4-(Trifluoromethyl)Phenylglyoxal Hydrate
CAS No.	1049746-22-6
Molecular Formula	C₉H₇F₃O₃
Molecular Weight	220.15 g/mol
Synonyms	2-Oxo-2-[4-(trifluoromethyl)phenyl]acetaldehyde Hydrate; 4-(Trifluoromethyl)benzoylformaldehyde Hydrate; α-Oxo-4-(trifluoromethyl)benzeneacetaldehyde Hydrate; (4-Trifluoromethylphenyl)glyoxal Hydrate; 4-(Trifluoromethyl)phenylglyoxal Monohydrate; 1-(4-Trifluoromethylphenyl)-1,2-ethanedione Hydrate; Phenylglyoxal, 4-(trifluoromethyl)-, Hydrate
EINECS	Contact for details

Quality Control

Every batch of 4-(Trifluoromethyl)Phenylglyoxal Hydrate is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing specifications such as assay (by HPLC), water content (KF), and impurity profiles. Our quality commitment aligns with cGMP principles where applicable, supporting our clients' regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	7.0% - 10.0% (as hydrate)
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.