Description

L-2-(((9H-Fluoren-9-Yl)Methoxy)Carbonylamino)-3-(2,4-Difluorophenyl)Propanoic Acid is a high-purity, non-natural amino acid derivative protected with the Fmoc (9-fluorenylmethoxycarbonyl) group, featuring a 2,4-difluorophenyl side chain. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the precise incorporation of fluorinated aromatic residues to modulate the biological activity, stability, and physicochemical properties of synthetic peptides. It is essential for researchers and manufacturers in pharmaceutical R&D, particularly for developing peptide-based therapeutics, diagnostic agents, and biochemical tools where fluorine substitution is strategically employed.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-protected amino acid, it is a fundamental monomer for the automated, sequential assembly of custom peptide sequences.
• Pharmaceutical Intermediate: Serves as a key raw material in the research and development of novel peptide drugs, including antimicrobial peptides (AMPs), hormone analogs, and targeted therapeutics.
• Fluorinated Peptide Library Construction: Used in combinatorial chemistry and high-throughput screening to create libraries of peptides containing difluorophenylalanine, exploring structure-activity relationships (SAR).
• Bioconjugation and Probe Development: The aromatic fluorine atoms and carboxylic acid group provide handles for further chemical modification, useful in creating fluorescent probes, affinity tags, or peptide-drug conjugates.
• Academic and Industrial Research: Employed in biochemical studies to investigate the role of fluorinated amino acids in protein folding, stability, and receptor binding interactions.

Basic Information

Product Name	L-2-(((9H-Fluoren-9-Yl)Methoxy)Carbonylamino)-3-(2,4-Difluorophenyl)Propanoic Acid
CAS No.	1049734-84-0
Molecular Formula	C24H19F2NO4
Molecular Weight	423.41 g/mol
Synonyms	Fmoc-2,4-difluoro-DL-phenylalanine; Fmoc-Dif-Phe-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-(2,4-difluorophenyl)-L-alanine; Fmoc-2,4-F2-Phe-OH; (2S)-2-[(9H-Fluoren-9-ylmethoxycarbonyl)amino]-3-(2,4-difluorophenyl)propanoic acid; Fmoc-L-2,4-difluorophenylalanine; Nα-Fmoc-2,4-difluorophenylalanine; Fmoc-(2,4-diF)Phe-OH
EINECS	Contact for details

Quality Control

Our L-2-(((9H-Fluoren-9-Yl)Methoxy)Carbonylamino)-3-(2,4-Difluorophenyl)Propanoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high chemical purity and chiral integrity, critical for reproducible peptide synthesis outcomes. Certificates of Analysis (COA) detailing purity (HPLC), specific rotation, and identity are provided with every shipment. We support compliance with cGMP guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This product is hygroscopic (moisture-sensitive); allow the sealed container to equilibrate to room temperature before opening to minimize moisture uptake. Keep under inert atmosphere (nitrogen or argon) for optimal shelf life after initial opening.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation [α]D20	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.