Description

4,4,5,5-Tetramethyl-2-(1,4-Dioxaspiro[4.5]Dec-7-En-7-Yl)-1,3,2-Dioxaborolane is a high-value, spirocyclic boronic ester building block essential for modern synthetic chemistry. Its primary value lies in enabling complex Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing carbon-carbon bonds under mild conditions. This compound is a critical reagent for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-purity intermediates for drug discovery and fine chemical synthesis.

Application

• Pharmaceutical Intermediate Synthesis: Key building block for constructing complex molecular architectures in active pharmaceutical ingredient (API) development and drug candidate libraries.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and insecticides that require specific spirocyclic structural motifs.
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a stable, handleable organoboron reagent for palladium-catalyzed coupling with aryl/vinyl halides or triflates.
• Material Science & Organic Electronics: Precursor for creating novel organic semiconductors, liquid crystals, and polymers with tailored electronic properties.
• Chemical Biology & Probe Development: Enables the synthesis of bioconjugates and molecular probes for studying biological systems.
• Academic & Industrial R&D: A versatile tool for methodological development and exploring new chemical space in synthetic organic chemistry.

Basic Information

Product Name	4,4,5,5-Tetramethyl-2-(1,4-Dioxaspiro[4.5]Dec-7-En-7-Yl)-1,3,2-Dioxaborolane
CAS No.	1049730-46-2
Molecular Formula	C17H27BO4
Molecular Weight	306.21 g/mol
Synonyms	7-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1,4-dioxaspiro[4.5]dec-7-ene; 1,4-Dioxaspiro[4.5]dec-7-ene-7-boronic acid pinacol ester; 7-Borono-1,4-dioxaspiro[4.5]dec-7-ene pinacol ester; Spiro[1,3,2-dioxaborolane-2,2'-[1,4]dioxaspiro[4.5]dec]-7'-ene, 4,4,5,5-tetramethyl-; 1,4-Dioxaspiro[4.5]dec-7-en-7-ylboronic acid pinacol ester; 7-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1,4-dioxaspiro[4.5]dec-7-ene
EINECS	Contact for details

Quality Control

Our 4,4,5,5-Tetramethyl-2-(1,4-Dioxaspiro[4.5]Dec-7-En-7-Yl)-1,3,2-Dioxaborolane is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. All material is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles as determined by advanced analytical techniques including NMR and HPLC. We support cGMP compliance for pharmaceutical applications and can provide material meeting specific customer specifications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (argon or nitrogen) after opening to prevent moisture absorption and decomposition. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.