Description

1-(2,2-Difluoroethyl)-4-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazole is a high-purity, advanced pharmaceutical intermediate and versatile synthetic building block. This compound is critical for enabling modern cross-coupling reactions, particularly the Suzuki-Miyaura reaction, which is fundamental to constructing complex molecules in medicinal chemistry. It is primarily needed by research institutions and pharmaceutical companies engaged in the discovery and development of new active pharmaceutical ingredients (APIs), agrochemicals, and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, especially in oncology, CNS, and antiviral research.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides with improved efficacy.
• Material Science: Serves as a precursor for boron-containing polymers and advanced organic electronic materials.
• Suzuki-Miyaura Cross-Coupling: The boronate ester group makes it an essential reagent for forming carbon-carbon bonds under mild conditions.
• Medicinal Chemistry SAR Studies: Enables the rapid exploration of structure-activity relationships by introducing the difluoroethyl-pyrazole motif.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting global drug development pipelines.

Basic Information

Product Name	1-(2,2-Difluoroethyl)-4-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazole
CAS No.	1049730-40-6
Molecular Formula	C11H17BF2N2O2
Molecular Weight	258.08 g/mol
Synonyms	4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-(2,2-difluoroethyl)-1H-pyrazole; 1-(2,2-Difluoroethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole; 1H-Pyrazole, 1-(2,2-difluoroethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; 1-(2,2-Difluoroethyl)-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole; 1-(Difluoroethyl)-4-(pinacolboranyl)pyrazole; 1049730-40-6; 4-Pinacolatoboryl-1-(2,2-difluoroethyl)pyrazole
EINECS	Contact for details

Quality Control

Our 1-(2,2-Difluoroethyl)-4-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazole is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing purity, impurities, and other critical parameters are provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, it is recommended to store the product under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation. Recommended storage temperature is 2-8°C for optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.