Description

Ethyl 2,5-Difluorobenzoylformate is a specialized fluorinated aromatic ester building block of significant interest in advanced organic synthesis. Its core value lies in its reactive α-ketoester functionality flanked by fluorine substituents, enabling precise molecular construction for complex target molecules. This compound is primarily needed by research and development chemists and process scale-up teams within the pharmaceutical and agrochemical industries, where it serves as a key intermediate for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing difluorophenyl motifs for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the fluorine atoms contribute to improved efficacy and environmental profile.
• Material Science Research: Serves as a monomer or building block for developing novel fluorinated polymers and advanced organic materials with specific optical or electronic properties.
• Chemical Biology & Probe Development: Employed in the creation of fluorinated molecular probes and tags for studying biological mechanisms and diagnostic applications.
• Custom Synthesis & Contract Manufacturing: A key starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	Ethyl 2,5-Difluorobenzoylformate
CAS No.	1049131-01-2
Molecular Formula	C₁₀H₈F₂O₃
Molecular Weight	214.17 g/mol
Synonyms	Ethyl 2,5-difluoro-α-oxobenzeneacetate; 2,5-Difluorobenzoylformic Acid Ethyl Ester; Ethyl (2,5-Difluorophenyl)(oxo)acetate; Ethyl Oxo(2,5-difluorophenyl)acetate; α-Oxo-2,5-difluorobenzeneacetic Acid Ethyl Ester; Ethyl 2,5-Difluorophenylglyoxylate; Ethyl 2,5-Difluorobenzoylformate
EINECS	Contact for details

Quality Control

Every batch of Ethyl 2,5-Difluorobenzoylformate is produced and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive synthetic applications. A detailed Certificate of Analysis (COA) specifying identity, purity, and impurity profiles is supplied with each shipment to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry, and well-ventilated area. Recommended long-term storage temperature is 2-8°C. Allow the sealed container to reach ambient temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.