Description

tert-Butyl 4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-yl)piperidine-1-carboxylate is a high-purity, protected piperidine boronic ester derivative that serves as a critical building block in modern synthetic chemistry. Its primary value lies in enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex carbon-carbon bonds. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-quality intermediates for drug discovery and fine chemical synthesis.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules containing functionalized piperidine scaffolds.
• Suzuki-Miyaura Cross-Coupling: Serves as a versatile boronic ester coupling partner for the introduction of the 4-piperidine moiety into complex molecular architectures.
• Drug Discovery & Medicinal Chemistry: Used extensively in parallel and combinatorial library synthesis for hit-to-lead optimization and structure-activity relationship (SAR) studies.
• Agrochemical Synthesis: Employed in the development of novel herbicides, fungicides, and insecticides that require specific heterocyclic structures.
• Ligand and Catalyst Development: Useful for constructing novel chiral ligands or organocatalysts based on the piperidine framework.
• Material Science Research: Potential building block for organic electronic materials or metal-organic frameworks (MOFs) requiring precise molecular geometry.

Basic Information

Product Name	tert-Butyl 4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-yl)piperidine-1-carboxylate
CAS No.	1048970-17-7
Molecular Formula	C16H30BNO4
Molecular Weight	311.23 g/mol
Synonyms	1-Boc-4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)piperidine; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)piperidine-1-carboxylic acid tert-butyl ester; tert-Butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-piperidinecarboxylate; 1-N-Boc-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)piperidine; 4-Pinacolatoboron-1-Boc-piperidine; 1-Boc-4-piperidineboronic acid pinacol ester; 4-(Boc)piperidine-4-boronic acid pinacol ester; Piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl) ester
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-yl)piperidine-1-carboxylate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical characterization, including NMR, HPLC, and MS, to confirm identity and purity. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes. We support development and commercial projects requiring compliance with cGMP and ICH Q7 guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Recommended long-term storage temperature is 2-8°C (refrigerated). Allow the sealed container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.