Description

Lithium [6-(1,3-Dioxolan-2-Yl)Pyridin-2-Yl]Triisopropoxyborate is a specialized organoboron reagent featuring a protected aldehyde functionality on a pyridine scaffold. This compound is a critical intermediate in modern synthetic chemistry, valued for its role in facilitating complex carbon-carbon and carbon-heteroatom bond formations. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug candidates, particularly those containing pyridine and boronic ester moieties for Suzuki-Miyaura cross-coupling reactions.
• Agrochemical Synthesis: Used in the research and development of new pesticides and herbicides, leveraging its structural features to create novel bioactive molecules.
• Material Science Research: Serves as a precursor for the development of organic electronic materials, ligands for catalysts, and metal-organic frameworks (MOFs).
• Chemical Biology Probes: Employed in the creation of tagged molecules and probes for studying biological pathways and protein interactions.
• Process Chemistry Development: Utilized in scaling up synthetic routes from laboratory to pilot plant scale for commercial production.
• Academic & Industrial R&D: A valuable reagent for methodology development and exploring new synthetic transformations in both university and corporate research laboratories.

Basic Information

Product Name	Lithium [6-(1,3-Dioxolan-2-Yl)Pyridin-2-Yl]Triisopropoxyborate
CAS No.	1048030-50-7
Molecular Formula	C17H27BLiNO5
Molecular Weight	343.15 g/mol
Synonyms	Lithium (6-(1,3-Dioxolan-2-yl)pyridin-2-yl)triisopropoxyborate; 2-(1,3-Dioxolan-2-yl)-6-(triisopropoxyboryl)pyridine Lithium Salt; 6-(1,3-Dioxolan-2-yl)pyridine-2-boronic Acid Triisopropyl Ester Lithium Complex; Lithium 6-(2,2-Dimethyl-1,3-dioxolan-4-yl)pyridin-2-yltriisopropoxyborate (related protected form); Pyridine-2-boronic Acid, 6-(1,3-dioxolan-2-yl)-, Triisopropyl Ester, Lithium Complex; Borate(1-), [6-(1,3-dioxolan-2-yl)-2-pyridinyl]triisopropoxy-, lithium; Lithium Organotriisopropoxyborate Reagent.
EINECS	Contact for details

Quality Control

Our production of Lithium [6-(1,3-Dioxolan-2-Yl)Pyridin-2-Yl]Triisopropoxyborate adheres to stringent quality management protocols to ensure batch-to-batch consistency and reliability for critical synthetic applications. Each lot undergoes comprehensive analysis including NMR (1H, 13C, 11B), HPLC for purity assessment, and Karl Fischer titration for moisture content. Certificates of Analysis (COA) detailing all specifications and test results are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (argon or nitrogen). Due to its hygroscopic and moisture-sensitive nature, the container must be handled in a dry, controlled environment and allowed to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0 %
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.