Description

(3S,4R)-4-o-Tolylpyrrolidine-3-Carboxylic Acid is a high-purity, chiral pyrrolidine derivative serving as a critical building block in advanced organic synthesis. Its value lies in its defined stereochemistry, which is essential for creating enantiomerically pure compounds with specific biological activities. This intermediate is primarily needed by pharmaceutical R&D and fine chemical manufacturers developing novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring precise molecular targeting.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel drug candidates, especially for central nervous system (CNS) and metabolic disorder targets.
• Asymmetric Synthesis: Used as a ligand or catalyst component in stereoselective chemical reactions to produce single-enantiomer products.
• Protease Inhibitor Development: Serves as a core structural motif in the design of enzyme inhibitors due to its pyrrolidine carboxylic acid scaffold.
• Chemical Biology Research: Employed in the synthesis of molecular probes and tool compounds for studying biological pathways and target validation.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke advanced intermediates under cGMP conditions.
• Academic Research: Utilized in university and institutional laboratories for methodological development in organic and medicinal chemistry.

Basic Information

Item	Details
Product Name	(3S,4R)-4-o-Tolylpyrrolidine-3-Carboxylic Acid
CAS No.	1047651-73-9
Molecular Formula	C13H17NO2
Molecular Weight	219.28 g/mol
Synonyms	(3S,4R)-4-(2-Methylphenyl)pyrrolidine-3-carboxylic acid; (3S,4R)-4-(o-Tolyl)-3-pyrrolidinecarboxylic acid; 4-(2-Methylphenyl)-L-threo-pyrrolidine-3-carboxylic acid; (3S,4R)-4-(2-Methylphenyl)-3-pyrrolidinecarboxylic Acid; (3S,4R)-4-(2-Tolyl)pyrrolidine-3-carboxylic acid; (3S,4R)-4-(o-Methylphenyl)pyrrolidine-3-carboxylic acid; (3S,4R)-4-(2-Methylphenyl)-3-carboxypyrrolidine
EINECS	Contact for details

Quality Control

Our (3S,4R)-4-o-Tolylpyrrolidine-3-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric purity and NMR for structural confirmation, to ensure compliance with exacting research and pharmaceutical-grade standards. Comprehensive Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.