Description

1,4-Dimethyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazole is a high-purity, synthetically valuable boronic ester derivative, serving as a critical building block in modern organic synthesis. Its core value lies in enabling efficient cross-coupling reactions, which are fundamental for constructing complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials industries who require reliable, high-quality intermediates for drug discovery and specialty chemical production.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel active pharmaceutical ingredients (APIs) and drug candidates.
• Agrochemical Synthesis: Used in the development of new pesticides, herbicides, and fungicides by facilitating the introduction of the pyrazole-boronate moiety.
• Material Science Research: Employed in the creation of organic electronic materials, such as OLEDs and semiconductors, where precise molecular construction is required.
• Chemical Biology & Proteomics: Acts as a versatile handle for bioconjugation and the synthesis of molecular probes and inhibitors.
• Catalyst Ligand Synthesis: Serves as a starting material for preparing sophisticated ligand systems used in homogeneous catalysis.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and research institutions for bespoke synthesis projects and library generation.

Basic Information

Item	Detail
Product Name	1,4-Dimethyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazole
CAS No.	1047644-76-7
Molecular Formula	C11H19BN2O2
Molecular Weight	222.10 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1,4-dimethyl-1H-pyrazole; 1,4-Dimethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole; 1,4-Dimethyl-1H-pyrazole-5-boronic acid pinacol ester; 1,4-Dimethylpyrazole-5-boronic acid pinacol ester; 1,4-Dimethyl-5-pyrazoleboronic acid pinacol ester; 1,4-Dimethyl-5-(pinacolatoboryl)-1H-pyrazole; CAS 1047644-76-7
EINECS	Contact for details

Quality Control

Our 1,4-Dimethyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP guidelines where applicable, ensuring reliability for research and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation and maintain purity. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.