Description

5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-2,3-Dihydro-1,4-Dioxine is a high-value organoboron building block, specifically a protected boronic ester derivative, essential for modern synthetic chemistry. Its core value lies in enabling Suzuki-Miyaura cross-coupling reactions, a pivotal method for constructing complex carbon-carbon bonds with high efficiency and selectivity. This compound is primarily needed by pharmaceutical R&D and agrochemical laboratories for synthesizing novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, particularly for coupling with aryl/heteroaryl halides to create biaryl structures common in active pharmaceutical ingredients (APIs).
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides by constructing specific aromatic and heterocyclic frameworks.
• Material Science Research: Serves as a monomer or building block for creating novel organic electronic materials, such as those used in OLEDs and organic photovoltaics.
• Ligand and Catalyst Development: Employed in the preparation of sophisticated ligands and organometallic catalysts for asymmetric synthesis and other catalytic processes.
• Chemical Biology Probes: Utilized to synthesize tagged molecules or bioconjugates for studying biological pathways and target engagement.
• Academic & Contract Research: A fundamental reagent in academic laboratories and CROs (Contract Research Organizations) for methodological development and library synthesis.

Basic Information

Item	Details
Product Name	5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-2,3-Dihydro-1,4-Dioxine
CAS No.	1046811-97-5
Molecular Formula	C12H21BO4
Molecular Weight	240.11 g/mol
Synonyms	2,3-Dihydro-1,4-dioxin-5-ylboronic acid pinacol ester; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydro-1,4-dioxin; 1,4-Dioxin-5-boronic acid, 2,3-dihydro-, pinacol ester; 5-Pinacolatoboryl-2,3-dihydro-1,4-dioxine; Dihydro-1,4-dioxin-5-ylboronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-2,3-Dihydro-1,4-Dioxine is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, critical for sensitive coupling reactions. All products undergo rigorous analytical testing, including NMR (1H, 13C, 11B) and HPLC analysis. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, it is recommended to handle the material under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and to minimize exposure to ambient humidity during use. Recommended storage temperature: 2-8°C (refrigerated) for optimal long-term stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.