Description

4-[4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-3-Cyclohexen-1-Yl]-Morpholine is a high-value, advanced pharmaceutical intermediate featuring a unique cyclohexenyl-morpholine scaffold protected by a pinacol boronate ester group. This compound matters because it serves as a critical building block in modern synthetic chemistry, enabling efficient cross-coupling reactions like the Suzuki-Miyaura reaction to construct complex molecular architectures. It is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, as well as by fine chemical manufacturers producing specialized materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, particularly those targeting central nervous system (CNS) disorders and other therapeutic areas.
• Suzuki-Miyaura Cross-Coupling: The pinacol boronate ester group makes it an excellent reagent for forming carbon-carbon bonds with aryl/vinyl halides, a cornerstone reaction in medicinal chemistry.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides that require the incorporation of the morpholine and cyclohexene motifs.
• Material Science: Serves as a monomer or functionalizing agent in the creation of advanced polymers and organic electronic materials.
• Chemical Biology & Proteomics: Can be utilized as a building block for activity-based probes or bioconjugation reagents due to its reactive handle.
• Academic & Contract Research: Essential for synthetic methodology development and the exploration of new chemical spaces in university and CRO laboratories.

Basic Information

Product Name	4-[4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-3-Cyclohexen-1-Yl]-Morpholine
CAS No.	1046793-56-9
Molecular Formula	C16H28BNO3
Molecular Weight	293.21 g/mol
Synonyms	4-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)cyclohex-3-en-1-yl)morpholine; 4-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-3-cyclohexen-1-yl)morpholine; Morpholine, 4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-cyclohexen-1-yl]-; 4-(4-(Pinacolatoboryl)cyclohex-3-en-1-yl)morpholine; 3-Cyclohexene-1-morpholine, 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-
EINECS	Contact for details

Quality Control

Our production of 4-[4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-3-Cyclohexen-1-Yl]-Morpholine adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including NMR, HPLC, and GC, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific client or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, it is recommended to store the product under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation. Recommended storage temperature is 2-8°C for optimal stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.