Description

5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Isothiazole is a high-value organoboron building block, specifically an isothiazole boronic ester, essential for modern synthetic chemistry. This compound serves as a critical intermediate in cross-coupling reactions, enabling the efficient construction of complex molecular architectures. It is primarily utilized by pharmaceutical R&D teams, agrochemical scientists, and advanced materials researchers for developing novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key building block in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, particularly in kinase inhibitor and antiviral research.
• Agrochemical Synthesis: Used to create advanced active ingredients for crop protection products, leveraging the isothiazole moiety for biological activity.
• Material Science Research: Employed in the development of organic electronic materials, such as OLEDs and semiconductors, where precise molecular engineering is required.
• Ligand & Catalyst Development: Serves as a precursor for synthesizing specialized ligands and catalysts used in homogeneous catalysis.
• Chemical Biology Probes: Utilized in the synthesis of labeled compounds and molecular probes for studying biological systems and mechanisms.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs serving the life sciences industry.

Basic Information

Product Name	5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Isothiazole
CAS No.	1045809-78-6
Molecular Formula	C9H14BNO2S
Molecular Weight	211.09 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2-thiazole; Isothiazole-5-boronic acid pinacol ester; 5-(Tetramethyl-1,3,2-dioxaborolan-2-yl)isothiazole; 5-Isothiazoleboronic Acid Pinacol Ester; 5-Boronoisothiazole Pinacol Ester; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-δ2-isothiazoline; PINACOL 5-ISOTHIAZOLYLBORONATE
EINECS	Contact for details

Quality Control

Our 5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Isothiazole is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality systems are designed to meet the stringent requirements of pharmaceutical and advanced R&D applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥97.0%
Purity (NMR)	Conforms
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Single Unknown Impurity (HPLC)	≤1.0%
Total Impurities (HPLC)	≤3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.