Description

1-Methyl-1H-Pyrazole-5-Boronic Acid Neopentyl Glycol Ester is a protected boronic acid derivative, a crucial building block in modern synthetic chemistry. Its primary value lies in its enhanced stability compared to the free boronic acid, making it a superior reagent for Suzuki-Miyaura cross-coupling reactions. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it is used to construct complex heterocyclic scaffolds for active ingredient development.

Application

• Pharmaceutical Intermediates: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing pyrazole or complex aryl-heterocycle motifs.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides that require specific heterocyclic structures.
• Material Science: Serves as a monomer or building block for creating advanced organic electronic materials, such as those used in OLEDs or organic semiconductors.
• Chemical Biology & Medicinal Chemistry: Employed in the discovery and optimization of drug candidates through combinatorial chemistry and parallel synthesis.
• Catalyst Ligand Synthesis: Used to prepare sophisticated ligand systems for transition metal catalysis.
• Custom Synthesis & Contract Manufacturing: A vital reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	1-Methyl-1H-Pyrazole-5-Boronic Acid Neopentyl Glycol Ester
CAS No.	1044851-76-4
Molecular Formula	C9H15BN2O2
Molecular Weight	194.04 g/mol
Synonyms	1-Methyl-1H-pyrazol-5-ylboronic acid neopentyl glycol ester; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-methyl-1H-pyrazole; 1-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole; 1-Methyl-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole; 1-Methyl-1H-pyrazole-5-boronic acid pinacol ester; Pyrazole boronic ester, 1-methyl-; Boronic acid, B-(1-methyl-1H-pyrazol-5-yl)-, 1,1-dimethylethylene ester
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure batch-to-batch consistency and compliance with industry standards. Standard quality control includes identification by spectroscopic methods (NMR, IR), purity assessment by HPLC, and verification of residual solvent levels. Certificates of Analysis (COA) detailing all specifications are available upon request. We adhere to cGMP principles where applicable to support our clients in regulated markets.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.