Description

2-[4-(Boc-Amino)-1-Piperidinyl]Pyridine-5-Boronic Acid Pinacol Ester is a high-value, protected boronic ester building block designed for advanced pharmaceutical synthesis. This compound matters because it provides a chemically stable and reactive handle for Suzuki-Miyaura cross-coupling reactions, a cornerstone of modern drug discovery. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex heterocyclic molecules and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, particularly in kinase inhibitor and central nervous system (CNS) therapeutic programs.
• Suzuki-Miyaura Cross-Coupling: Serves as a versatile boronic ester reagent for forming carbon-carbon bonds between aromatic and heteroaromatic systems under mild conditions.
• Peptidomimetic & PROTAC Synthesis: Used in constructing complex molecules that mimic peptides or for developing Proteolysis Targeting Chimeras (PROTACs) due to its protected amine and boronic acid functionalities.
• Agrochemical Research: Employed in creating new active ingredients for crop protection with enhanced efficacy and selectivity.
• Material Science: Potential use in synthesizing organic electronic materials and metal-organic frameworks (MOFs) requiring specific piperidine-pyridine architectures.
• Chemical Biology Probes: Useful for labeling and studying biological processes due to its bifunctional reactivity.

Basic Information

Product Name	2-[4-(Boc-Amino)-1-Piperidinyl]Pyridine-5-Boronic Acid Pinacol Ester
CAS No.	1042917-44-1
Molecular Formula	C21H32BN3O4
Molecular Weight	401.31 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-[4-[(tert-butoxycarbonyl)amino]-1-piperidinyl]pyridine; 2-(4-((tert-Butoxycarbonyl)amino)piperidin-1-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; tert-Butyl N-[1-[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl]piperidin-4-yl]carbamate; Boc-4-Amino-1-(5-Bpin-2-pyridyl)piperidine; 2-(4-(Boc-amino)piperidin-1-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 5-Boronic acid pinacol ester-2-(4-Boc-amino-1-piperidinyl)pyridine; CAS 1042917-44-1
EINECS	Contact for details

Quality Control

Our 2-[4-(Boc-Amino)-1-Piperidinyl]Pyridine-5-Boronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and LC-MS for identity verification, to ensure compliance with exacting R&D and process chemistry standards. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.