Description

3-Chlorothiophene-2-Boronic Acid Pinacol Ester is a high-value organoboron building block, specifically a boronic ester derivative of a halogenated thiophene. Its core value proposition lies in enabling precise Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex molecules in modern synthetic chemistry. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require a stable, reactive intermediate for introducing the 3-chlorothiophene moiety into target structures.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), especially those containing functionalized thiophene cores.
• Agrochemical Synthesis: Used in creating novel herbicides, fungicides, and insecticides that leverage the chlorothiophene scaffold.
• Material Science Research: Employed in the development of organic semiconductors, conductive polymers, and non-linear optical materials.
• Ligand & Catalyst Development: Serves as a precursor for synthesizing specialized ligands used in catalysis.
• Chemical Library Construction: A valuable reagent for medicinal chemistry and drug discovery programs focused on creating diverse compound libraries.
• Custom Synthesis: Used in contract research and manufacturing (CRO/CMO) for bespoke chemical synthesis projects.

Basic Information

Product Name	3-Chlorothiophene-2-Boronic Acid Pinacol Ester
CAS No.	1040281-97-7
Molecular Formula	C10H14BClO2S
Molecular Weight	244.55 g/mol
Synonyms	2-(3-Chlorothiophen-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 3-Chloro-2-thienylboronic acid pinacol ester; (3-Chloro-2-thienyl)boronic acid pinacol ester; 3-Chlorothiophene-2-boronic acid neopentyl glycol ester (common alternative); 3-Chloro-2-thiopheneboronic acid pinacol ester; Pinacol (3-chlorothiophen-2-yl)boronate; CAS 1040281-97-7
EINECS	Contact for details

Quality Control

Our 3-Chlorothiophene-2-Boronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment ensures batch-to-batch consistency, which is critical for your research and development reproducibility.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry, and well-ventilated place. Recommended long-term storage temperature is 2-8°C. The compound is easily oxidized and should be handled under inert conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.