Description

2-(4-Chlorothiophen-2-Yl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is a high-purity boronic ester derivative, a critical building block in modern synthetic organic chemistry. Its core value lies in enabling efficient and selective cross-coupling reactions, such as the Suzuki-Miyaura reaction, which is fundamental for constructing complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors, where it is used to introduce functionalized thiophene moieties into target molecules. The CAS number for this compound is 1040281-84-2.

Application

This versatile boronic ester is a key intermediate in the synthesis of complex organic molecules. Its primary and related applications include:

• Pharmaceutical Intermediate: Used in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing chlorinated thiophene scaffolds.
• Agrochemical Synthesis: Serves as a building block for creating novel herbicides, fungicides, and insecticides with tailored properties.
• Material Science: Employed in the development of organic electronic materials, such as semiconductors for OLEDs and organic photovoltaics (OPVs).
• Chemical Research: A valuable reagent in academic and industrial R&D for exploring new synthetic pathways and creating novel chemical entities via palladium-catalyzed cross-coupling.
• Ligand and Catalyst Development: Used to synthesize complex ligands for catalysis or as a precursor for functional materials.

Basic Information

Item	Details
Product Name	2-(4-Chlorothiophen-2-Yl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane
CAS No.	1040281-84-2
Molecular Formula	C10H15BClO2S
Molecular Weight	244.55 g/mol
Synonyms	4-Chloro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)thiophene; 2-(4-Chloro-2-thienyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 4-Chlorothiophene-2-boronic acid pinacol ester; (4-Chlorothiophen-2-yl)boronic acid pinacol ester; Pinacol (4-chlorothiophen-2-yl)boronate
EINECS	Contact for details

Quality Control

Our 2-(4-Chlorothiophen-2-Yl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC, to ensure high chemical purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, it is recommended to store the product under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Recommended storage temperature is 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.