Description

2-Bromo-4-Fluoro-1-(Methylsulfonyl)Benzene is a high-purity, multi-functional aromatic building block designed for advanced synthetic chemistry. This compound matters as a key intermediate for introducing both bromo and fluoro substituents alongside a versatile methylsulfonyl group into complex molecular architectures. It is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and material science industries who require reliable, high-quality intermediates for drug discovery and specialty chemical synthesis.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the development of novel herbicides and fungicides, where the fluorine and bromine atoms enhance biological activity and environmental stability.
• Material Science Research: Acts as a monomer or functionalization agent in the creation of specialty polymers and liquid crystals with tailored electronic properties.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form complex biaryl structures.
• Sulfone Chemistry Exploration: The methylsulfonyl group is a valuable handle for further functionalization, including as an activating group for nucleophilic aromatic substitution.
• Fluorine Chemistry Building Block: Provides a stable source of a fluorine-substituted aromatic ring for constructing fluorinated compounds with improved metabolic stability and membrane permeability.

Basic Information

Product Name	2-Bromo-4-Fluoro-1-(Methylsulfonyl)Benzene
CAS No.	1039744-23-4
Molecular Formula	C7H6BrFO2S
Molecular Weight	253.09 g/mol
Synonyms	1-Bromo-2-fluoro-5-(methylsulfonyl)benzene; 2-Bromo-4-fluorophenyl methyl sulfone; 4-Fluoro-2-bromophenyl methyl sulfone; Methyl 2-bromo-4-fluorophenyl sulfone; (2-Bromo-4-fluorophenyl)(methyl)sulfone; Benzene, 2-bromo-4-fluoro-1-(methylsulfonyl)-; 1039744-23-4
EINECS	Contact for details

Quality Control

Our 2-Bromo-4-Fluoro-1-(Methylsulfonyl)Benzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specification parameters. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong oxidizing agents, strong bases, and sources of ignition. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Melting Point	Contact for details
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.