Description

6-Chloro-9A-(2-Fluoroethyl)-7-Methoxy-9,9A-Dihydro-1H-Fluoren-3(2H)-One is a high-purity, advanced pharmaceutical intermediate characterized by its unique fluorenone core structure with chloro, fluoroethyl, and methoxy substituents. This compound is critical for the synthesis of novel active pharmaceutical ingredients (APIs) and complex organic molecules, offering a versatile building block for medicinal chemistry research and development. It is primarily utilized by pharmaceutical R&D laboratories, fine chemical manufacturers, and academic institutions engaged in the development of new therapeutic agents.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly in central nervous system (CNS) and oncology research.
• Medicinal Chemistry Research: Used for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Organic Synthesis: Serves as a versatile precursor for constructing complex polycyclic frameworks in advanced organic synthesis.
• Fine Chemical Production: Employed in the manufacture of specialty chemicals and high-value fluorinated compounds.
• Academic & Industrial R&D: A valuable reagent for research in synthetic methodology and new material development.

Basic Information

Product Name	6-Chloro-9A-(2-Fluoroethyl)-7-Methoxy-9,9A-Dihydro-1H-Fluoren-3(2H)-One
CAS No.	1039456-85-3
Molecular Formula	C₁₇H₁₆ClFO₂
Molecular Weight	306.76 g/mol
Synonyms	6-Chloro-9A-(2-fluoroethyl)-7-methoxy-9,9a-dihydro-1H-fluoren-3(2H)-one; 6-Chloro-9a-(2-fluoroethyl)-7-methoxy-2,3,9,9a-tetrahydro-1H-fluoren-3-one; 1039456-85-3; 6-Chloro-9a-(2-fluoroethyl)-7-methoxy-1,2,9,9a-tetrahydro-3H-fluoren-3-one; Fluoren-3(2H)-one, 6-chloro-9a-(2-fluoroethyl)-7-methoxy-9,9a-dihydro-1H-; 6-Chloro-9a-(2-fluoroethyl)-7-methoxy-9,9a-dihydro-1H-fluoren-3(2H)-one; 6-Chloro-9a-(2-fluoroethyl)-7-methoxy-2,3,9,9a-tetrahydro-1H-fluoren-3-one (alternative numbering)
EINECS	Contact for details

Quality Control

Our 6-Chloro-9A-(2-Fluoroethyl)-7-Methoxy-9,9A-Dihydro-1H-Fluoren-3(2H)-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring a reliable supply for research and development purposes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. The container should be kept tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Maximum Impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.