Description

3,3-Difluoro-1-(Trifluoroacetyl)Piperidine-2-Carboxylic Acid is a high-value, multi-fluorinated piperidine derivative that serves as a critical building block in advanced organic synthesis. Its unique structure, featuring both difluoro and trifluoroacetyl moieties, makes it an indispensable intermediate for introducing fluorine atoms into complex molecules, thereby modulating their physicochemical and biological properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients, as well as by fine chemical manufacturers specializing in custom synthesis.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly for introducing fluorinated motifs to enhance metabolic stability, bioavailability, and binding affinity.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides, where fluorination is a common strategy to improve efficacy and environmental profile.
• Material Science Research: Serves as a precursor for developing novel fluorinated polymers, liquid crystals, or specialty chemicals with unique surface properties.
• Custom Synthesis & Contract Manufacturing: Employed by fine chemical companies for the bespoke synthesis of complex fluorinated molecules for client projects.
• Academic & Industrial R&D: A valuable reagent for methodological studies in organic chemistry, exploring new fluorination reactions and heterocyclic chemistry.

Basic Information

Product Name	3,3-Difluoro-1-(Trifluoroacetyl)Piperidine-2-Carboxylic Acid
CAS No.	1039364-78-7
Molecular Formula	C8H6F5NO3
Molecular Weight	259.13 g/mol
Synonyms	2-Carboxy-3,3-difluoro-1-(trifluoroacetyl)piperidine; 1-(Trifluoroacetyl)-3,3-difluoropiperidine-2-carboxylic acid; 3,3-Difluoro-1-(trifluoroacetyl)-2-piperidinecarboxylic acid; 3,3-Difluoro-1-(2,2,2-trifluoroacetyl)piperidine-2-carboxylic acid; Piperidine-2-carboxylic acid, 3,3-difluoro-1-(trifluoroacetyl)-; CAS 1039364-78-7
EINECS	Contact for details

Quality Control

Our 3,3-Difluoro-1-(Trifluoroacetyl)Piperidine-2-Carboxylic Acid is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, meeting the stringent requirements of research and production applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles. Our quality management system is designed to support cGMP and ISO standards for reliable supply to regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. Keep away from incompatible materials such as strong bases and fluorides.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Purity (HPLC, Area%)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.