Description

(3-Bromo-4-Fluorophenoxy)(tert-Butyl)Dimethylsilane is a high-purity organosilicon reagent featuring a halogenated aromatic ether group protected by a tert-butyldimethylsilyl (TBDMS) moiety. This compound is a critical building block in advanced organic synthesis, particularly for the controlled introduction of substituted phenoxy groups under mild conditions. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Serves as a key protected synthon in the multi-step synthesis of active pharmaceutical ingredients (APIs), especially those containing halogenated aromatic ether scaffolds.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides where the bromo-fluoro-phenoxy group confers specific biological activity.
• Liquid Crystal & OLED Materials: Acts as a precursor in the development of specialty chemicals for electronic displays and organic light-emitting diodes due to its stable silane protection and halogenated aromatic core.
• Polymer Modification: Employed to functionalize polymers and resins, imparting specific thermal, optical, or surface properties through the incorporation of the phenoxy silane group.
• Cross-Coupling Reactions: A valuable substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille) for creating biaryl and complex aromatic systems.
• Protecting Group Chemistry: The TBDMS group can be used to protect the phenolic oxygen during synthetic sequences, with subsequent deprotection allowing for further functionalization.

Basic Information

Product Name	(3-Bromo-4-Fluorophenoxy)(tert-Butyl)Dimethylsilane
CAS No.	1037088-98-4
Molecular Formula	C₁₂H₁₈BrFO Si
Molecular Weight	305.26 g/mol
Synonyms	tert-Butyl(3-bromo-4-fluorophenoxy)dimethylsilane; (3-Bromo-4-fluorophenoxy)-tert-butyldimethylsilane; 3-Bromo-4-fluorophenoxy-tert-butyldimethylsilane; 4-Fluoro-3-bromophenoxy-tert-butyldimethylsilane; TBDMS 3-bromo-4-fluorophenyl ether; Silane, (3-bromo-4-fluorophenoxy)(1,1-dimethylethyl)dimethyl-; 1-((tert-Butyldimethylsilyl)oxy)-2-bromo-4-fluorobenzene
EINECS	Contact for details

Quality Control

Our (3-Bromo-4-Fluorophenoxy)(tert-Butyl)Dimethylsilane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and elemental analysis, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for research and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.