Description

4-[3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzoyl]Morpholine is a high-purity, advanced pharmaceutical intermediate featuring a key boronic ester functional group. This compound is critical for enabling Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern medicinal chemistry for constructing complex biaryl structures. It is primarily utilized by research institutions and pharmaceutical companies engaged in the discovery and development of novel active pharmaceutical ingredients (APIs), particularly in oncology and central nervous system (CNS) therapeutic areas.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, especially those requiring complex biaryl linkages.
• Suzuki-Miyaura Cross-Coupling Reagent: Used in palladium-catalyzed carbon-carbon bond formation reactions to create complex molecular architectures in medicinal chemistry.
• Organic Synthesis Research: Employed in academic and industrial R&D labs for constructing functionalized morpholine and benzophenone derivatives.
• Agrochemical Development: Serves as a precursor in the synthesis of advanced crop protection agents and herbicides.
• Material Science: Potential use in the development of organic electronic materials and polymers via its reactive boronate group.
• Chemical Biology Probes: Utilized in the creation of tagged molecules for studying biological pathways and protein interactions.

Basic Information

Product Name	4-[3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzoyl]Morpholine
CAS No.	1036991-25-9
Molecular Formula	C17H24BNO4
Molecular Weight	317.19 g/mol
Synonyms	3-(Morpholine-4-carbonyl)phenylboronic acid pinacol ester; [3-(Morpholin-4-ylcarbonyl)phenyl]boronic acid pinacol ester; 4-[3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzoyl]morpholine; Morpholine, 4-[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoyl]-; 3-(4-Morpholinylcarbonyl)benzeneboronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our production of 4-[3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzoyl]Morpholine adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. All materials are subjected to rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment. Our quality system is designed to support cGMP compliance for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.