Description

3-((N,n-Dimethylamino)Methy)Phenyl Boronic Acid Pinacol Ester Hydrochloride is a high-value, protected boronic acid derivative that serves as a crucial synthetic intermediate in modern organic and medicinal chemistry. Its core value lies in its dual functionality, combining a protected boronate ester for stable handling and Suzuki-Miyaura cross-coupling reactions with a dimethylamino-methyl group that offers a versatile handle for further functionalization. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries who are developing new active ingredients, particularly in the synthesis of complex molecules where precise control over molecular architecture is required.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, especially in creating biaryl and heterobiaryl structures common in kinase inhibitors and other targeted therapies.
• Agrochemical Synthesis: Used in the research and development of new pesticides and herbicides, where the boronate ester enables efficient carbon-carbon bond formation to create diverse chemical scaffolds.
• Material Science Research: Employed in the development of organic electronic materials, such as polymers and small molecules for OLEDs or OFETs, where the introduction of specific aromatic groups is necessary.
• Ligand and Catalyst Development: Serves as a precursor for creating sophisticated ligands used in asymmetric catalysis or as a component in metal-organic frameworks (MOFs).
• Chemical Biology Probes: Utilized in the synthesis of tagged molecules and probes for studying biological pathways and protein interactions.
• Cross-Coupling Reactions: Primarily used in palladium-catalyzed Suzuki-Miyaura cross-coupling to form carbon-carbon bonds between aromatic rings, a cornerstone reaction in complex molecule assembly.

Basic Information

Product Name	3-((N,n-Dimethylamino)Methy)Phenyl Boronic Acid Pinacol Ester Hydrochloride
CAS No.	1036991-19-1
Molecular Formula	C15H25BClNO2
Molecular Weight	297.63 g/mol
Synonyms	[3-(Dimethylaminomethyl)phenyl]boronic acid pinacol ester hydrochloride; (3-((Dimethylamino)methyl)phenyl)boronic acid pinacol ester HCl; 3-(Dimethylaminomethyl)benzeneboronic acid pinacol ester hydrochloride; Pinacol [3-(N,N-dimethylaminomethyl)phenyl]boronate hydrochloride; B-[3-[(Dimethylamino)methyl]phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane hydrochloride; CAS 1036991-19-1; 3-(Dimethylaminomethyl)phenylboronic acid pinacol ester HCl salt
EINECS	Contact for details

Quality Control

Our 3-((N,n-Dimethylamino)Methy)Phenyl Boronic Acid Pinacol Ester Hydrochloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for research and process chemistry. Certificates of Analysis (COA) with detailed specifications are provided for each lot to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.