Description

1H-Pyrazole, 1-(2-Methylpropyl)-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)- is a high-value, functionalized pyrazole derivative containing a pinacol boronate ester group, making it a versatile building block for modern synthetic chemistry. This compound is critical for facilitating Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for forming carbon-carbon bonds under mild conditions. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors to construct complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly in medicinal chemistry for creating novel heterocyclic compounds.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides that require specific pyrazole-based scaffolds.
• Material Science Research: Serves as a precursor for creating organic electronic materials, such as ligands for OLEDs or conductive polymers.
• Chemical Biology & Proteomics: Employed in the synthesis of molecular probes and bioconjugation reagents for studying biological systems.
• Catalyst & Ligand Development: Utilized to synthesize novel ligands for transition metal catalysts used in asymmetric synthesis.
• Custom Synthesis & Contract Manufacturing: A critical reagent for custom synthesis houses and CROs/CMOs serving the life sciences industry.

Basic Information

Product Name	1H-Pyrazole, 1-(2-Methylpropyl)-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-
CAS No.	1036757-43-3
Molecular Formula	C₁₃H₂₅BN₂O₂
Molecular Weight	264.16 g/mol
Synonyms	1-Isobutyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole; 1-(2-Methylpropyl)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole; 3-(Pinacolatoboryl)-1-isobutyl-1H-pyrazole; 1-Isobutyl-1H-pyrazole-3-boronic acid pinacol ester; Pyrazole-3-boronic acid, 1-isobutyl-, pinacol ester; 1H-Pyrazole-3-boronic acid, 1-(2-methylpropyl)-, 1,1,1',1'-tetramethylenediyl ester
EINECS	Contact for details

Quality Control

Every batch of our 1H-Pyrazole, 1-(2-Methylpropyl)-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)- is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the product meets the high-purity standards required for sensitive cross-coupling reactions. A detailed Certificate of Analysis (COA) is supplied with each shipment, confirming identity, purity, and impurity profiles via validated methods such as NMR and HPLC.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and to maintain optimal reactivity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥97.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.