Description

1-Bromo-2-Butoxy-4-Fluorobenzene is a high-purity fluorinated aromatic building block of significant importance in advanced organic synthesis. Its molecular structure, featuring bromine, fluorine, and an alkoxy substituent, makes it a versatile intermediate for constructing complex molecules. This compound is primarily sought after by research institutions and pharmaceutical companies engaged in the development of new active pharmaceutical ingredients (APIs), agrochemicals, and specialty materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting CNS and anti-inflammatory applications.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides and pesticides, leveraging the fluorine atom for enhanced biological activity and metabolic stability.
• Liquid Crystal & OLED Material Research: Serves as a building block for creating fluorinated aromatic cores in electronic and photonic materials.
• Cross-Coupling Reactions: The bromine atom acts as an excellent handle for palladium-catalyzed reactions like Suzuki, Negishi, and Buchwald-Hartwig aminations.
• Chemical Biology Probes: Utilized in the design and synthesis of fluorinated probes and tags for imaging and diagnostic applications.
• Specialty Polymer Modification: Incorporated into polymer backbones to impart specific properties such as altered solubility, thermal stability, or chemical resistance.

Basic Information

Product Name	1-Bromo-2-Butoxy-4-Fluorobenzene
CAS No.	1036724-57-8
Molecular Formula	C₁₀H₁₂BrFO
Molecular Weight	247.11 g/mol
Synonyms	2-Bromo-1-butoxy-4-fluorobenzene; 4-Fluoro-2-bromo-1-butoxybenzene; 1-Butoxy-2-bromo-4-fluorobenzene; 2-Bromo-4-fluorophenyl butyl ether; Benzene, 1-bromo-2-butoxy-4-fluoro-; 1036724-57-8
EINECS	Contact for details

Quality Control

We maintain a rigorous quality management system to ensure batch-to-batch consistency and high purity. Our standard grade for 1-Bromo-2-Butoxy-4-Fluorobenzene typically meets a purity specification of ≥97% (by GC/HPLC), suitable for research and process development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment. We can also support development projects with custom purity grades upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.