Description

1H-Pyrrolo[2,3-B]Pyridine, 5-Methyl-1-[(4-Methylphenyl)Sulfonyl]-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)- is a high-purity, advanced pharmaceutical intermediate featuring a valuable boronic ester functional group. This compound matters as a critical building block in modern medicinal chemistry, enabling efficient cross-coupling reactions like the Suzuki-Miyaura reaction for constructing complex molecular architectures. It is primarily needed by research institutions and pharmaceutical companies engaged in the discovery and development of novel active pharmaceutical ingredients (APIs), particularly for oncology and central nervous system (CNS) therapeutics.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, especially kinase inhibitors and other targeted small-molecule therapies.
• Suzuki-Miyaura Cross-Coupling: The boronic ester moiety enables efficient carbon-carbon bond formation with aryl/heteroaryl halides, a cornerstone reaction in medicinal chemistry.
• Research & Development (R&D): Used in academic and industrial labs for exploring new chemical entities and structure-activity relationships (SAR).
• Process Chemistry: Serves as a building block in the scale-up and optimization of synthetic routes for potential Active Pharmaceutical Ingredients (APIs).
• Library Synthesis: Employed in the parallel and combinatorial synthesis of diverse compound libraries for high-throughput screening.
• Agrochemical Research: Potential intermediate in the development of new crop protection agents and pesticides.
• Material Science: Can be investigated as a monomer or precursor for functional organic materials and polymers.

Basic Information

Product Name	1H-Pyrrolo[2,3-B]Pyridine, 5-Methyl-1-[(4-Methylphenyl)Sulfonyl]-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-
CAS No.	1036028-17-7
Molecular Formula	C21H25BN2O4S
Molecular Weight	412.31 g/mol
Synonyms	5-Methyl-1-tosyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine; 1-Tosyl-5-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine; 3-Boronic acid, 5-methyl-1-[(4-methylphenyl)sulfonyl]-1H-pyrrolo[2,3-b]pyridine-, pinacol ester; 5-Methyl-1-tosyl-1H-pyrrolo[2,3-b]pyridine-3-boronic acid pinacol ester; 1036028-17-7; (5-Methyl-1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-yl)boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 1H-Pyrrolo[2,3-B]Pyridine, 5-Methyl-1-[(4-Methylphenyl)Sulfonyl]-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)- is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and development applications. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.