Description

1H-Pyrrolo[2,3-B]Pyridine, 1-[(4-Methylphenyl)Sulfonyl]-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-5-(Trifluoromethyl)- is a high-value, multi-functional boronic ester derivative designed for advanced synthetic chemistry. This compound is a critical building block in modern pharmaceutical research and development, offering a versatile handle for cross-coupling reactions. It is primarily utilized by medicinal chemists and process R&D teams in the pharmaceutical, agrochemical, and advanced materials sectors to construct complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics.
• Suzuki-Miyaura Cross-Coupling: The pinacol boronate ester group enables efficient carbon-carbon bond formation, essential for constructing biaryl and heterobiaryl structures in drug discovery.
• Medicinal Chemistry & Lead Optimization: Used to introduce the trifluoromethyl-substituted pyrrolopyridine scaffold, a privileged structure known to enhance metabolic stability, lipophilicity, and binding affinity.
• Agrochemical Research: Serves as a building block for developing novel crop protection agents and pesticides.
• Material Science: Potential intermediate in the synthesis of organic electronic materials and ligands for catalysts.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and scale-up services for the life sciences industry.

Basic Information

Product Name	1H-Pyrrolo[2,3-B]Pyridine, 1-[(4-Methylphenyl)Sulfonyl]-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-5-(Trifluoromethyl)-
CAS No.	1036027-60-7
Molecular Formula	C21H24BF3N2O4S
Molecular Weight	468.30 g/mol
Synonyms	1-[(4-Methylphenyl)sulfonyl]-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine; 1-Tosyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine; 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-tosyl-5-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine; 5-(Trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine-3-boronic acid pinacol ester, 1-tosyl-; 1H-Pyrrolo[2,3-b]pyridine-3-boronic acid, 1-[(4-methylphenyl)sulfonyl]-5-(trifluoromethyl)-, pinacol ester; 1036027-60-7; Boronic acid, B-[1-[(4-methylphenyl)sulfonyl]-5-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-, pinacol ester
EINECS	Contact for details

Quality Control

Every batch of this advanced intermediate is produced and analyzed under strict quality management systems. We provide comprehensive Certificates of Analysis (COA) detailing purity, identity, and impurity profiles to ensure it meets the exacting standards required for research and development. Our quality protocols are designed to support cGMP compliance for pharmaceutical applications, ensuring traceability, consistency, and reliability for our global B2B clients.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.